Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.5
USERS' SCORE
Good
Based on 8 Reviews
8.5
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Milk Thistle Phospholipid Proprietary BlendMilk thistle extract (fruit) [providing 480 mg silymarin, 180 mg silybin, 48 mg isosilybin A and isosilybin B], phospholipids
760 mg
**
SILIPHOS® phytosome milk thistle extract (fruit) [providing 47.52 mg silybin]
160 mg
**
Top Medical Research Studies
9.5
We investigated the potential heart health benefits of 2,3-dehydrosilybin (DHS), a component of silybum marianum. In our study, rats' isolated hearts were treated with low doses of DHS before experiencing induced heart attacks and subsequent recovery.
The results showed that DHS significantly reduced heart tissue damage compared to untreated hearts, suggesting it has a protective effect. This effect is linked to specific signaling pathways in the heart. Overall, our research highlights the promising cardioprotective properties of this natural compound.
The results showed that DHS significantly reduced heart tissue damage compared to untreated hearts, suggesting it has a protective effect. This effect is linked to specific signaling pathways in the heart. Overall, our research highlights the promising cardioprotective properties of this natural compound.
Read More
9.5
We explored the potential of Silybum marianum (SM) in combating cardiac lipotoxicity following myocardial infarction (MI) in a pig study. Over 10 days, animals received either SM or a placebo.
The results showed that SM significantly lowered plasma triglyceride levels and reduced triglyceride absorption, leading to less fat accumulation in the heart muscle after ischemic injury.
Importantly, the SM treatment was free of side effects, indicating its promise as a supportive therapy for heart disease without adverse reactions.
The results showed that SM significantly lowered plasma triglyceride levels and reduced triglyceride absorption, leading to less fat accumulation in the heart muscle after ischemic injury.
Importantly, the SM treatment was free of side effects, indicating its promise as a supportive therapy for heart disease without adverse reactions.
Read More
9
Milk thistle aids heart recovery
We explored how Silybum marianum, or milk thistle, can affect heart health, especially after a heart attack. In studies on pigs, we found that giving SM shortly before and after a heart attack helped reduce damage and improve recovery.
It showed potential in lowering oxidative stress and enhancing heart function. However, animals with no heart attack didn't experience these benefits. Our findings suggest that milk thistle could play a role in heart recovery during critical phases following a heart attack.
It showed potential in lowering oxidative stress and enhancing heart function. However, animals with no heart attack didn't experience these benefits. Our findings suggest that milk thistle could play a role in heart recovery during critical phases following a heart attack.
Read More
Most Useful Reviews
9
Fatty liver improvement
10 people found this helpful
I have been using this product regularly with phosphatidyl choline (PC) to rid myself of the dreaded NAFLD. My doctor informed me that the fatty liver disease is no longer present! Nonetheless, I continue taking this along with the PC after a fatty lunch each day. As of August 2021, I am still using it.
Read More
9
Fatty liver recovery
8 people found this helpful
I absolutely love this Milk Thistle! It is, in my opinion, the best one. I take numerous medications and supplements due to various ailments. At one point, I had fatty liver disease, which completely resolved once I introduced this particular brand of Milk Thistle alongside another I take (NOW Milk Thistle with Dandelion and Artichoke). I take one capsule of each, NOW brand in the morning and this one at night.
Read More
9
Recommendation for wellness
This is a top product. For anyone battling fatty liver disease, I highly recommend it. The effects it delivers are certain.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.5
- All Researches
9.5
We explored the potential of Silybum marianum (SM) in combating cardiac lipotoxicity following myocardial infarction (MI) in a pig study. Over 10 days, animals received either SM or a placebo.
The results showed that SM significantly lowered plasma triglyceride levels and reduced triglyceride absorption, leading to less fat accumulation in the heart muscle after ischemic injury.
Importantly, the SM treatment was free of side effects, indicating its promise as a supportive therapy for heart disease without adverse reactions.
The results showed that SM significantly lowered plasma triglyceride levels and reduced triglyceride absorption, leading to less fat accumulation in the heart muscle after ischemic injury.
Importantly, the SM treatment was free of side effects, indicating its promise as a supportive therapy for heart disease without adverse reactions.
Read More
9.5
We investigated the potential heart health benefits of 2,3-dehydrosilybin (DHS), a component of silybum marianum. In our study, rats' isolated hearts were treated with low doses of DHS before experiencing induced heart attacks and subsequent recovery.
The results showed that DHS significantly reduced heart tissue damage compared to untreated hearts, suggesting it has a protective effect. This effect is linked to specific signaling pathways in the heart. Overall, our research highlights the promising cardioprotective properties of this natural compound.
The results showed that DHS significantly reduced heart tissue damage compared to untreated hearts, suggesting it has a protective effect. This effect is linked to specific signaling pathways in the heart. Overall, our research highlights the promising cardioprotective properties of this natural compound.
Read More
9
Milk thistle aids heart recovery
We explored how Silybum marianum, or milk thistle, can affect heart health, especially after a heart attack. In studies on pigs, we found that giving SM shortly before and after a heart attack helped reduce damage and improve recovery.
It showed potential in lowering oxidative stress and enhancing heart function. However, animals with no heart attack didn't experience these benefits. Our findings suggest that milk thistle could play a role in heart recovery during critical phases following a heart attack.
It showed potential in lowering oxidative stress and enhancing heart function. However, animals with no heart attack didn't experience these benefits. Our findings suggest that milk thistle could play a role in heart recovery during critical phases following a heart attack.
Read More
8
We explored the effects of silymarin on heart and liver health in a study involving 28 male mice. The animals were divided into groups and treated with silymarin, saline, and paracetamol to simulate oxidative stress.
The results showed that silymarin significantly reduced liver damage and inflammation caused by paracetamol and also demonstrated protective effects in cardiac tissue. While these findings highlight its potential as a treatment for heart and liver issues, further research is needed to confirm how effective silymarin is in humans.
The results showed that silymarin significantly reduced liver damage and inflammation caused by paracetamol and also demonstrated protective effects in cardiac tissue. While these findings highlight its potential as a treatment for heart and liver issues, further research is needed to confirm how effective silymarin is in humans.
Read More
8
We explored how 2,3-dehydrosilybin (DHS), a component of Silybum marianum, may protect heart cells from damage caused by a lack of oxygen. The study involved cultured rat heart cells subjected to hypoxia and reoxygenation, which is a common stress for heart tissue. Our findings revealed that while DHS treatment reduced the harmful production of reactive oxygen species, it did not improve cell viability. Thus, while DHS offers some protective effects, significant benefits for heart health remain unconfirmed.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Fatty liver improvement
10 people found this helpful
I have been using this product regularly with phosphatidyl choline (PC) to rid myself of the dreaded NAFLD. My doctor informed me that the fatty liver disease is no longer present! Nonetheless, I continue taking this along with the PC after a fatty lunch each day. As of August 2021, I am still using it.
Read More
9
Fatty liver recovery
8 people found this helpful
I absolutely love this Milk Thistle! It is, in my opinion, the best one. I take numerous medications and supplements due to various ailments. At one point, I had fatty liver disease, which completely resolved once I introduced this particular brand of Milk Thistle alongside another I take (NOW Milk Thistle with Dandelion and Artichoke). I take one capsule of each, NOW brand in the morning and this one at night.
Read More
9
Recommendation for wellness
This is a top product. For anyone battling fatty liver disease, I highly recommend it. The effects it delivers are certain.
Read More
9
Supports liver health
Repurchase for protecting the liver and helps with fatty liver disease. I will continue to buy it for life.
Read More
7.5
Improved condition
I love alcohol! I enjoy dinner with my husband every night, so I'll keep taking this! I've been having one tablet in the morning and one at night, and I feel that my physical condition has improved significantly.
Read More
Frequently Asked Questions
7.5
Improved condition
I love alcohol! I enjoy dinner with my husband every night, so I'll keep taking this! I've been having one tablet in the morning and one at night, and I feel that my physical condition has improved significantly.
9
Fatty liver recovery
8 people found this helpful
I absolutely love this Milk Thistle! It is, in my opinion, the best one. I take numerous medications and supplements due to various ailments. At one point, I had fatty liver disease, which completely resolved once I introduced this particular brand of Milk Thistle alongside another I take (NOW Milk Thistle with Dandelion and Artichoke). I take one capsule of each, NOW brand in the morning and this one at night.
7.5
Effective heart supplement
Good product, quality and value for money. My father occasionally takes it due to his heart disease. When possible, he asks me to purchase this supplement for him. The package size and quantity are reasonable. Overall, I liked the product; it is a reliable supplement.
9
Supports liver health
Repurchase for protecting the liver and helps with fatty liver disease. I will continue to buy it for life.
9
Fatty liver improvement
10 people found this helpful
I have been using this product regularly with phosphatidyl choline (PC) to rid myself of the dreaded NAFLD. My doctor informed me that the fatty liver disease is no longer present! Nonetheless, I continue taking this along with the PC after a fatty lunch each day. As of August 2021, I am still using it.
7.5
Liver protection
Milk Thistle contains the flavonoid silymarin, vital for its protective benefits to the liver. It offers antioxidant, antiviral, and anti-inflammatory properties! It combats liver disease and mitigates liver injury stemming from various drugs and environmental toxins. Furthermore, it exhibits potential anticancer and antidiabetic benefits while supporting kidney, brain, and heart health.
7
Vitamin benefits
The vitamins are good, likely suitable for everyone, though one should consult a nutritionist. Nowadays, living without vitamins is almost impossible! They are of high quality and I strongly recommend them. The taste may not suit everyone, but when taken correctly, they greatly benefit the skin, heart, and cardiovascular system.
8
We explored the effects of silymarin on heart and liver health in a study involving 28 male mice. The animals were divided into groups and treated with silymarin, saline, and paracetamol to simulate oxidative stress.
The results showed that silymarin significantly reduced liver damage and inflammation caused by paracetamol and also demonstrated protective effects in cardiac tissue. While these findings highlight its potential as a treatment for heart and liver issues, further research is needed to confirm how effective silymarin is in humans.
The results showed that silymarin significantly reduced liver damage and inflammation caused by paracetamol and also demonstrated protective effects in cardiac tissue. While these findings highlight its potential as a treatment for heart and liver issues, further research is needed to confirm how effective silymarin is in humans.
9.5
We explored the potential of Silybum marianum (SM) in combating cardiac lipotoxicity following myocardial infarction (MI) in a pig study. Over 10 days, animals received either SM or a placebo.
The results showed that SM significantly lowered plasma triglyceride levels and reduced triglyceride absorption, leading to less fat accumulation in the heart muscle after ischemic injury.
Importantly, the SM treatment was free of side effects, indicating its promise as a supportive therapy for heart disease without adverse reactions.
The results showed that SM significantly lowered plasma triglyceride levels and reduced triglyceride absorption, leading to less fat accumulation in the heart muscle after ischemic injury.
Importantly, the SM treatment was free of side effects, indicating its promise as a supportive therapy for heart disease without adverse reactions.
9
Milk thistle aids heart recovery
We explored how Silybum marianum, or milk thistle, can affect heart health, especially after a heart attack. In studies on pigs, we found that giving SM shortly before and after a heart attack helped reduce damage and improve recovery.
It showed potential in lowering oxidative stress and enhancing heart function. However, animals with no heart attack didn't experience these benefits. Our findings suggest that milk thistle could play a role in heart recovery during critical phases following a heart attack.
It showed potential in lowering oxidative stress and enhancing heart function. However, animals with no heart attack didn't experience these benefits. Our findings suggest that milk thistle could play a role in heart recovery during critical phases following a heart attack.
8
We explored how silymarin, particularly its active component silibinin, might protect the heart and liver from damage caused by the cancer drug doxorubicin in male Wistar rats. By giving a dose of 60 mg/kg of silymarin orally for 12 days while administering doxorubicin every other day, we monitored various factors such as body weight, ECG changes, and biochemical markers.
Our findings indicated that silymarin effectively provided protective effects against the toxic damage associated with doxorubicin, showcasing its potential benefits for heart health.
Our findings indicated that silymarin effectively provided protective effects against the toxic damage associated with doxorubicin, showcasing its potential benefits for heart health.
References
- Okiljević B, Martić N, Govedarica S, Andrejić Višnjić B, Bosanac M, et al. Cardioprotective and Hepatoprotective Potential of Silymarin in Paracetamol-Induced Oxidative Stress. Pharmaceutics. 2024;16. 10.3390/pharmaceutics16040520
- Vilahur G, Sutelman P, Mendieta G, Ben-Aicha S, Borrell-Pages M, et al. Triglyceride-induced cardiac lipotoxicity is mitigated by Silybum marianum. Atherosclerosis. 2021;324:91. 10.1016/j.atherosclerosis.2021.03.014
- Gabrielová E, Bartošíková L, Nečas J, Modrianský M. Cardioprotective effect of 2,3-dehydrosilybin preconditioning in isolated rat heart. Fitoterapia. 2019;132:12. 10.1016/j.fitote.2018.10.028
- Vilahur G, Casaní L, Peña E, Crespo J, Juan-Babot O, et al. Silybum marianum provides cardioprotection and limits adverse remodeling post-myocardial infarction by mitigating oxidative stress and reactive fibrosis. Int J Cardiol. 2018;270:28. 10.1016/j.ijcard.2018.06.030
- Gabrielová E, Křen V, Jabůrek M, Modrianský M. Silymarin component 2,3-dehydrosilybin attenuates cardiomyocyte damage following hypoxia/reoxygenation by limiting oxidative stress. Physiol Res. 2015;64:79.
- Reuland DJ, Khademi S, Castle CJ, Irwin DC, McCord JM, et al. Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress. Free Radic Biol Med. 2013;56:102. 10.1016/j.freeradbiomed.2012.11.016
- Anestopoulos I, Kavo A, Tentes I, Kortsaris A, Panayiotidis M, et al. Silibinin protects H9c2 cardiac cells from oxidative stress and inhibits phenylephrine-induced hypertrophy: potential mechanisms. J Nutr Biochem. 2013;24:586. 10.1016/j.jnutbio.2012.02.009
- Rašković A, Stilinović N, Kolarović J, Vasović V, Vukmirović S, et al. The protective effects of silymarin against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats. Molecules. 2011;16:8601. 10.3390/molecules16108601
